The topic of this paper is related to the student population and their attitudes, related to sexually responsible behavior and sexual knowledge. It is known that adolescents in early adolescence face a great challenge in terms of sexuality due to many biological as well as psychological changes, such as menstrual attack, voice change (puberphony) in boys, the development of secondary sexual characteristics. The attitude of family and society, as well as the cultural influence on these changes, during puberty, plays a major role in deciding on adolescent sexual behavior after puberty. The final paper on the topic "Students 'knowledge of sexually responsible behavior" aimed to determine students' knowledge of sexually responsible behavior and whether students behave sexually responsibly. It consists of two parts, the first part of which talks in general about adolescence and the changes that occur in it, sexual health and sexually responsible behavior, and methods of sexually responsible behavior. Sexually transmitted diseases and their prevention are also briefly described, as well as the importance of going to a gynecological examination and maintaining intimate hygiene. The second part of the paper describes the conducted research. A total of 334 students were analyzed. Answers to 29 questions were analyzed and the answers to all the questions are presented through graphs that describe the results numerically and in percentages.