Venous ulcer may be defined as an area of discontinuity of the epidermis and dermis on the lower leg, which doesn’t heal in period longer than 4 weeks. It appears to be the most severe consequence of chronic venous insufficiency. The risk factors for the development of the venous ulcer are vein varices, a positive family history, long-term sitting and standing, overcome deep vein thrombosis, congestive heart failure, decreased body activity, obesity, edema and trauma. The most common localization of the ulcer is on the medial ankle. They are mostly large, superficial and with abundant exudate. The most common venous ulcer complications are infections. Periodontitis, ankylosis, osteomyelitis and osteoporosis may also occur. Venous ulcer diagnosis is based on anamnesis, clinical signs, routine laboratory examination, Doppler UZV, oximetry, phlebography and angiography. Differential diagnosis includes all ulcerations of the lower extremities of the other etiology or ulcers resulting from trauma, infection, arteriosclerosis, autoimmune diseases, neoplastic diseases and bites of insects. The goal of the treatment is to accelerate healing of the venous ulcer, increase the work ability of the patient, and reduce the length and cost of treatment. Treatment of venous ulcer can be local and systematic. Local treatment is focused directly on venous ulceration and local skin changes and systemic treatment is focused on remove risk factors and existing comorbidities. The most effective therapy of venous ulcer is compressive therapy. The nurse has a significant role in the diagnosis, treatment and prevention of venous ulceration and patient education. Nurse assessment, nurse diagnosis and interventions create a health care plan designed to accelerate healing of venous ulcers and prevent relapse.