Considering the considerable advancements of CAD / CAM technology in the last decade in the field of fixed prosthodontics and taking into account longevity and frequent imprecision in making a complete denture in a conventional way, it could have been expected that a similar upset would occur in mobile prosthodontics. Despite the difficulties experienced by pioneers of this technology, it is now more perfect in several variants available on the market. Although there is not much research, almost all of it suggests CAD / CAM dentures over conventional when considering precision, speed, patient comfort, retention, stabilization, biocompatibility, chemical and mechanical properties. All CAD / CAM molding systems have their advantages and disadvantages, but all CAD / CAM manufacturing methods are superior to the conventional way of making a full prosthesis and today it is possible to produce a complete denture in only 2 patient visits. By using software for denture design, the dental technician avoids some physical procedures such as modeling, individual trays, bite rims, flasking and teeth setting. Most of these procedures are performed by a computer aided milling machine. Milled pre-polymerized acrylic block exhibits better chemical and mechanical properties than the conventional denture base and higher biotolerance due to less porosity. The basic problem of this technology is that it requires a skilled therapist with a certain clinical experience and good education in the field of complete dentures and their CAD / CAM design.