Pain is the most common symptom of trauma patients. Although recognized and treated, the pain in these patients was most often underestimated symptom treated with aninsufficient amount of medication. That is either due to an incomplete evaluation of the patient's condition, underestimation of pain intensity (because the pain is very different in different patients) or for fear of patient sedation (vital function depression or distorting clinical picture of a patient important in assessing injury). Nurses are the most intensive of all healthcare professionals in contact with the patient. They must evaluate the patient in terms of his health condition, the type of injury and the intensity of the pain he is suffering, as well as the other health problems the patient has, the medication he is consuming, and the psychological and social condition he or she has. Accurate assessment of the cause of pain intensity can significantly contribute to a quality of therapeutic approach, initiating preventive analgesia, balanced pharmacological or multimodal analgesia, and performing nonpharmacological analgesic procedures. Nurses evaluate pain often, and especially after each intervention that can change the pain intensity. For pain estimation, some instruments such as visual-analogue pain scores, facies pain scales, numeric scales of pain are used. There are instruments used in dementia and poorly communicating patients (Abbey scale, PAIN-AD, Bolton scale , bievioral scale). In the pain treatment protocols, nurses are part of a multidisciplinary team with the anesthesiologist, surgeon and clinical pharmacologist. The basis of proper pain treatment is medication therapy - opioid drugs are core of analgesic therapy, and in the multimodal approach they must be combined with nonsteroidal anti-inflammatory drugs, anticonvulsants, and local and regional analgesic procedures and medications. Nurses are concerned about the implementation of the pain treatment protocol, and additionally they are obligatory to conduct non-medicated procedures for the treatment of pain; cryotherapy, relaxation procedures, massage, change of position, etc. Their role is also in educating patients and their families on the importance of regular analgesia, the way drugs are administered, drug doses and possible side effects of medication therapy.