Malignant tumors of the nose and paranasal sinuses are not common among the general population. The complexity of the anatomy of the sinonasal region and its proximity to vital structures such as the eyes, brain, and cranial nerves pose significant challenges for its treatment. Because of the unspecific symptoms in the early stage of the disease, the diagnosis is usually made only after the tumor has reached an advanced stage. Treatment includes a surgery, radiation and chemotherapy or a combination of all three therapeutic options. A retrospective analysis is presented of 83 patients with a malignant tumors of the nose and paranasal sinuses treated between 2005 and 2016. This study was conducted at the Department of Otolaryngology and Head and Neck Surgery in the University Hospital Sisters of Mercy. The patients’ ages ranged from 2 to 89 years, with an average of 59,9 years. In our study, squamous cell carcinoma was the most frequent histological tumor type, followed by adenocarcinoma. The five-year survival rate was consistent with the relevant literature. We noticed that in few patients intraoperatively some tumors even in higher T stages do not exhibit infiltrative growth but cause premodilation of surrounding structures. Although these are several isolated cases, they suggest that the biological behavior of the tumor does not depend only on histological diagnosis. Relatively low incidence and histological diversity of these tumors complicate making of guidelines for treatment that would be consinstent with Evidence Based Medicine.