Objective: The objective of this research is to examine the existence and level of unfavourable physical factors of the environment as a source of stress for patients in the intensive care unit and claim the contribution factors as stressors on the quality of life of hospitalized patients. Subjects and methods: The sample of respondents made up of 39 patients hospitalized at the clinic for Anesthesiology, reanimatology and intensive care in KBC Split. The survey was conducted using a questionnaire which the respondents fill in from March to April to June 2017. Results: Patients included in the survey were differ significantly by gender and age structure, and the length of the duration of hospitalization in a wide range. The segment that stands out in terms of patients' satisfaction with various aspects of the provision of health care services is the satisfaction with the health care and the conducts of nurses relationship. The subjects were also lowly rated information given about the disease and treatment plan. In addition, by examining the predictors of multidrug-resistant stress for hospitalized patients up notable category of concern for health. The analysis of the results which the respondents assessed the environmental factors like physical agents whose presence or action may have to be coupled with causality stress, the most notable factors were related to lighting and air circulation, followed by a noise in the room. Among a group of subjects over which the research was conducted, circumstance of physical agents environment were not cnofirmed as statistically significant. The dominant feature of a predictive stress during hospitalization, respondents expressed in variables of concern for future health.