Coronary heart disease and stroke are the leading causes of death in the world. Primary prevention measures can reduce the risk of cardiovascular disease after a patient has been accurately assessed. However, risk assessment methods based on traditional risk factors (i.e. Framingham risk score, SCORE) fail to directly reveal the presence of the most common cause of cardiovascular disease – atherosclerosis. Ageing is considered a major and irreversible risk factor for cardiovascular disease. Age-related gradual changes of vascular structure and function start early in life. Most of the complex mechanisms that lead to degenerative changes in the arterial wall are common with those mediating atherosclerosis. B-mode ultrasound measurement of carotid intima-media thickness (cIMT) is a reproducible, noninvasive and relatively low-cost method of determining the presence of subclinical atherosclerosis without any known adverse effects. Epidemiological studies have shown that cIMT is significantly and independently correlated with future cardiovascular events. Nevertheless, the usefulness of adding cIMT to the traditional risk factors is still questionable as risk stratification improvement is limited. On the basis of the estimated age- and sex- specific percentile of cIMT, patients' chronological age can be adjusted for their atherosclerotic burden, a concept that is called vascular age. Reducing risk factors for cardiovascular disease could lead to slower progression of early atherosclerotic changes. Obesity is a significant and independent risk factor for cardiovascular disease and it is related to the increased value and faster progression of cIMT. The objective of this paper is to investigate whether weight loss reduces cIMT in obese subjects. The study followed 19 obese subjects which participated in weight reduction program under medical supervision. At six-month follow-up subjects were divided into three groups based on the extent of weight loss. However, results did not find statistically significant differences between groups.