Objectives: The topic of this review paper is to highlight the main therapeutic problems in the treatment of patients with schizophrenia, to indicate the impact of achieving a therapeutic goal on quality of life, and how this can be altered by the use of injectable long-acting, monthly and quarterly drug formulations, in this case paliperidone-palmitate. Material and methods: For the purpose of the research, various available sources of information were reviewed such as professional publications published in relevant journals, professional and scientific literature, diagnostic and statistical manuals needed for diagnosis, current therapeutic guidelines, Croatian Medicines and Medicinal Products Database, Medicines Registry for 2018 and other sources available. Results: Important therapeutic problems in the treatment of patients with schizophrenia are presented, such as poor compliance and the occurrence of relapses, most often due to the significant side effects of registered oral antipsychotics used in the treatment. For this purpose, the available literature on the topic of long-acting intramuscular drug paliperdon-palmitate, the efficacy and safety of its administration, differences with oral therapy, impact on adherence, improvement of quality of life and achievement of therapeutic goal were reviewed. Conclusion: The use of paliperidone-palmitate and other depot preparations has been shown to reduce the concomitant use of several different antipsychotics, reduce the number of possible interactions and side effects of drugs, improve adherence and therapeutic response, and thus reduce the number of rehospitalizations, prolong the time in remission, which also causes reducing the burden on the overall health system. Consequently, the patient's relationship with the family, but also with the chosen doctor is improved, and, most importantly, the quality of life of the patient is improved and he is enabled to live and earn his own living.