Urinalysis has a large importance for the detection of kidney and urinary tract disease. This is why it is important for the report indicate of pathological condition to be accurate, precise and issued on time. Standardization of procedures for the collection, transport, sample preparation and analysis are a key segment of effective strategies for the urinalysis. In accordance with good laboratory practice, prior to the introduction of such a fully automated device, it is necessary to carry out verification, or check the manufacturer's specifications, who performed extensive validation. The purpose of verification is to check whether the analyzer is suitable for work in the laboratory in which it is going to be used. In this study, positive and negative controls were examined, which were taken and analyzed for five days in triplicate to determine interprecision, repeatability and the percentage of agreement. Satisfactory results were obtained for all analytes with minor deviations to the cobas u601 control 65821 for glucose. In addition, 400 urine samples were processed, which were compared with the analyzer, which is the routine application, and microscopic examination of urine sediment as a reference method. The results show deviations within the results regarding erythrocytes in the chemical analysis of urine, as well as deviations in composition results for bacteria as a test parameter in the microscopic analysis of the urinary sediment. The observed differences are attributed to methodological differences between the different analyzers when testing the same analyte. Verification fully automated urinalysis system Cobas® 6500 conducted in this thesis has shown satisfactory results and analyzer is acceptable for routine work in the lab.