Radiofrequency electromagnetic field in the human environment is mainly caused by mobile communication systems. Mobile phones are the most rapidly growing telecommunication technology worldwide which is shown by the fact that in the last ten years their use has increased three times. It created justified concerns about potential adverse effects which are focused on development of brain tumors. It is known that tumors can occur when exposed to ionizing radiation because it changes the structure of the irradiated substance. But non-ionizing radiation which has not such a large energy to eject the electron out of atoms shells and thus ionize the substance, can’t directly damage the cells of a biological organism in a chemical level. Although there were a lot of research about influence of the radiation on the human body, tumor cells and tumor development itself, it is still not fully understood. Many of the results is different and it is still not known the exact impact of mobile phones. The International Agency for Research on Cancer in 2011 classified the radiofrequency radiation to a group of potential carcinogenic to humans. Until now, the majority of published studies conducted on the use of mobile phones and brain tumors have not shown an increased risk as regards the overall use. Nevertheless, the obtained results were positive in several subgroups, as is the case with the long-term users and analog phones where in both cases the risk of developing tumors is slightly elevated. In addition, radiation consequently effect on human health by destroying the DNA molecule and altering the expression of genes and proteins in the body. In order to confirm previous theses and closely clarify the impact of mobile radiation on biological organisms, they need to be supported by additional data from future studies.