Religion involves beliefs, practices and rituals related to the sacred with the aim to reach transcendent. It may also involve beliefs about spirits, both good (angels) and bad (demons). Religion originates in an established tradition that arises at of a community with common beliefs and practices while spirituality implies a broader aspect of religiosity. Spirituality is associated with issues related to the significance and purpose of life, with the belief in spiritualistic aspects in order to justify one’s existence and significance. Over the last few decades, scientific research in the area of health has been carried out with the objective of studying the possible influences of spirituality on health status of human beings. Results indicates positive correlations, that is, protective factor od religiosity and spirituality in sense of mental health. Holistic approach implies provision of comprehensive care that identifies physical, emotional, social, economic, and spiritual needs. Interventions using a holistic approach is most beneficial in psychiatric care nursing.