Ankylosing spondylitis is a chronic systemic rheumatic disease characterized by an inflammatory process as part of pathological changes occurring in the spine. Sometimes it can also affect other joints, such as the shoulder or hip joint. Changes can also affect visceral organs (iridocyclitis, enthesitis or changes in the aortic valves). The basic pathological anatomical process is inflammation of the sacroiliac joints, which, with its progressive character, spreads throughout the entire area, causing pain and stiffness of the spine. It is extremely important to recognize the symptoms of the disease as early as possible and start treatment immediately. Treatment consists of physical therapy, kinesitherapy and education. Of the physical modalities used in the treatment of ankylosing spondylitis, hydrotherapy, ultrasound, diathermy, electrotherapy, phototherapy, magnetotherapy, medical massage and underwater massage are primarily used. All these procedures improve the outcome of the treatment by reducing the painful area of the spine and root joints, maintaining and restoring the function of the patient's muscles, regulating the circulation and metabolic processes of the organism, increasing muscle strength, relaxing tense connective structures, which helps to reduce existing contractures. In addition to all the above, the main task of the entire process of physiotherapy treatment, kinesitherapy and education is to avoid the patient's disability. At the end of the treatment, it is important to educate the patient about the newly learned habits and postural positions that he should apply during professional activities and activities of daily life. He should also be encouraged to practice a physiotherapy program at home every day and to engage in some sports such as swimming. The outcome of the ankylosing spondylitis disease will depend on the patient's adherence to the physiotherapist's instructions at the end of the physiotherapy treatment program.