In adolescence, a special focus of the person is placed on developing friendly relationships. Since self-esteem is decreasing in the period of adolescence self-esteem due to various maturation changes, it is important to focus on the social mechanisms that could present protective factors. Research suggests that close friendships could be an important factor. Based on the aforementioned, the aim of the study was, on an appropriate sample of adolescents, to determine the relationship between friendship attachment and self-esteem. The study included a total of 107 participants (54 girls and 53 boys from high schools in Zadar and Trogir, the average age= 15.49 years). In this research translated and adapted Wilkinson's Adolescent Friendship Attachment Scale (AFAS) and the Rosenberg Self Esteem scale were used. Results indicate that boys show a greater level of self-esteem than girls. Also, girls show a greater security in friendship attachment than boys, while boys show greater avoidance. There was no difference in anxiety in friendly relationships between girls and boys. A significant moderate correlation was determined between attachment dimension anxiety and self-esteem which indicate that greater anxiety in friendly relationships is associated with lower self-esteem. Complementary results were also obtained by an analysis between these variables separately for girls and boys, more specifically, girls and boys with a lower level of self-esteem reported a greater anxiety in friendly relationships. There was no significant difference between security and avoidance in friendship and self-esteem, which was also shown in the separate analysis of the results of boys and girls.