As a part of this thesis, a design solution for heating, cooling and air conditioning system of the printing plant building located in the city of Zagreb was made. The air conditioning system of the production line of the printing plant was designed as an air-water system with and air conditioning unit for air preparation, and fan coil units as cooling bodies at peak loads. The printing warehouse was designed as an air system with its own air conditioning unit for air preparation. For both air conditioning units, hot water with a temperature regime of 70/60°C is used as a heating medium, and water with a temperature regime od 7/12°C is used as a cooling medium. A two-pipe water system with fan coil units was designed for the rest of the printing plant building. Cooling water is prepared centrally with two chillers. Calculation of the heat load for the winter period was made according to the standard HRN EN 12831, and for the summer period according to the standard VDI 2078. Ventilation requirements of the production line and warehouse were calculated with the permissible concentration od volatile organic compounds, but due to the fact that excessive values of the required air flow rate were obitained, it was decided to design a ventilation system so that contaminants are removed locally by displacement ventilation with lower air flow rates. When sizing the components of the air conditioning units, two operating modes were taken into account: when the printing machines are working and when they are not working. In addition to the calculation and selection of equipment, this thesis also contains a scheme of the functional conections and control scheme, as well as drawings that define the layout and installation of the selected equipment.