Pulmonary embolism, together with deep vein thrombosis, is a manifestation of venous thromboembolism. The outcome of pulmonary embolism depends on the severity of the disease and the treatment strategy. Treatment of pulmonary embolism should be started as early as possible, as morbidity and mortality are the greatest in the acute period. A retrospective study was conducted among patients treated in Intensive care unit of the Sestre Milosrdnice University Hospital Centre in the period between January 1st 2018 and December 31st 2018. The aim of the study was to analyze the frequency and outcomes of pulmonary embolism in the unit. The study included 761, including 88 pulmonary acute pulmonary embolism. The majority of patients (n = 79) with pulmonary embolism were admitted from the Emergency Department and were predominantly female (64.8%). The median age of the patients was 74 years with a range of 30 to 91 years. There was a statistically significant difference (p = 0.002) in the median age, which was 66 (30-85) years for men, while the median age for women was 76 (42-91) years. The most common chronic diseases were arterial hypertension (70.5% of patients), peripheral arterial diseases (38.6% of patients), malignancy (28.4% of patients) and diabetes (27.3% of patients). In relation to the total mortality of 23.4%, the mortality from pulmonary embolism was 12.5%. Patients who died from PE had significantly higher SAPS II (p <0.001) and significantly lower GCS (p <0.001) and were significantly more often treated for shock, compared with those who survived PE (p <0.001). The length of stay ranged from 1 to 14 days, with a median of 5 days. Pulmonary embolism remains an important clinical problem associated with high mortality with the old age of the subjects, comorbid conditions and severity of the clinical picture largely responsible for such an outcome. Our results are consistent with the results of larger European and world studies. Early recognition of the risk and diagnosis of pulmonary embolism as well as the initiation of treatment are extremely important, because in the first hours after the onset of this condition, the probability of an unfavorable outcome is the highest.