Učinak kvercetina u prevenciji razvoja osteoporoze štakora

Stanušić, Ena

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master's thesis

Učinak kvercetina u prevenciji razvoja osteoporoze štakora

Zagreb: University of Zagreb, Faculty of Science, 2011. urn:nbn:hr:217:077209

Stanušić, Ena

University of Zagreb
Faculty of Science
Department of Biology

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APA 6th Edition

Stanušić, E. (2011). Učinak kvercetina u prevenciji razvoja osteoporoze štakora (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:077209

MLA 8th Edition

Stanušić, Ena. "Učinak kvercetina u prevenciji razvoja osteoporoze štakora." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:077209

Chicago 17th Edition

Stanušić, Ena. "Učinak kvercetina u prevenciji razvoja osteoporoze štakora." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:077209

Harvard

Stanušić, E. (2011). 'Učinak kvercetina u prevenciji razvoja osteoporoze štakora', Master's thesis, University of Zagreb, Faculty of Science, accessed 24 January 2025, https://urn.nsk.hr/urn:nbn:hr:217:077209

Vancouver

Stanušić E. Učinak kvercetina u prevenciji razvoja osteoporoze štakora [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2011 [cited 2025 January 24] Available at: https://urn.nsk.hr/urn:nbn:hr:217:077209

IEEE

E. Stanušić, "Učinak kvercetina u prevenciji razvoja osteoporoze štakora", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:217:077209

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:077209

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Title	Učinak kvercetina u prevenciji razvoja osteoporoze štakora
Title (english)	The effect of quercetin in the prevention of osteoporosis in rats
Author	Ena Stanušić
Mentor	Nada Oršolić (mentor)
Committee member	Nada Oršolić (predsjednik povjerenstva)
Committee member	Alan Moro (član povjerenstva)
Committee member	Mladen Kerovec (član povjerenstva)
Committee member	Danijel Orešić (član povjerenstva)
Granter	University of Zagreb Faculty of Science (Department of Biology) Zagreb
Defense date and country	2011-03-17, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Biology
Abstract	Kvercetin je flavonol iz skupine flavonoida i jedan od važnijih fitoestrogena prisutan u većim količinama u luku, jabuci i grožđu. Istražen je utjecaj kvercetina na osteoporozu te mogućnost njegove uporabe u prevenciji razvoja osteoporoze u štakora soja Y-59. U prvom dijelu istraživanja tijekom 15 dana, životinje su intragastričnim putem obrađene retinoičnom kiselinom u dozi od 80 mg kg-1 uz primjenu kvercetina u dozi od 100 mg kg-1 iIli alendronata (40 mg kg-1). U drugom dijelu istraživanja životinje su tijekom 15 dana obrađene samo kvercetinom i alendronatom. Određena je ukupna razina kalcija i fosfora iz desnih femura životinja te hematološki i biokemijski pokazatelji. Za procjenu genotoksičnosti korišten je komet test te mikronukleus test. Kvercetin je pokazao povoljan učinak na mineralnu gustoću kosti, a da pritom nije izazvao nikakve štetne učinke na organizam. Rezultati ovog istraživanja daju nadu da kvercetin može biti učinkovit u prevenciji osteoporoze ili redukciji štetnih učinaka lijekova koji mogu prouzročiti osteoporozu i da može biti upotrebljen u obradi osteoporoze u ljudi.
Abstract (english)	Quercetin is a flavonol from the flavonoid group and one of the major phytoestrogens present in higher amounts in onions, apples and grapes. The effect of quercetin on osteoporosis and the possibility of its use in preventing the development of osteoporosis in Y-59 rats were investigated. In the first part of the study during 15 days, the animals were intragatricly treated with retinoic acid at dose of 80 mg kg-1 with quercetin (100 mg kg-1) and/or alendronate (40 mg kg-1). In the second part of the study animals were treated during the 15 days only with quercetin and alendronate. The total levels of calcium and phosphorus from the right femur of the animals, and hematological and biochemical parameters were determined. For the assessment of genotoxicity we used comet assay and the micronucleus test. Quercetin showed a beneficial effect on the mineral bone density, while it did not cause any damage in the body. In addition, the results of the present study in rats have given us the hope that quercetin can confer in the prevention of osteoporosis or the reduction of the side effects due to drug-induced osteoporosis, and may be used in humans in the management of osteoporosis in vivo.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:077209
Study programme	Title: Enviromental Sciences Study programme type: university Study level: graduate Academic / professional title: magistar/magistra struke znanosti o okolišu (magistar/magistra struke znanosti o okolišu)
Type of resource	Text
File origin	Born digital
Access conditions	Access restricted to students and staff of home institution
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Repository	Repository of the Faculty of Science
Created on	2017-05-03 10:07:59