Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava

Jurišić, Matea

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master's thesis

Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava

Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:489556

Jurišić, Matea

University of Zagreb
Faculty of Science
Department of Biology

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APA 6th Edition

Jurišić, M. (2023). Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:489556

MLA 8th Edition

Jurišić, Matea. "Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:489556

Chicago 17th Edition

Harvard

Jurišić, M. (2023). 'Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava', Master's thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:489556

Vancouver

Jurišić M. Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:489556

IEEE

M. Jurišić, "Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:489556

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Metadata

Title	Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava
Title (english)	Antimicrobial resistance of Enterobacteriaceae isolates from human urogenital system
Author	Matea Jurišić
Mentor	Jasna Hrenović (mentor)
Committee member	Jasna Hrenović (predsjednik povjerenstva)
Committee member	Petra Peharec Štefanić (član povjerenstva)
Committee member	Petar Kružić (član povjerenstva)
Committee member	Silvija Černi (član povjerenstva)
Granter	University of Zagreb Faculty of Science (Department of Biology) Zagreb
Defense date and country	2023-09-27, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Biology
Abstract	Antibiotici su farmakološke tvari koje zaustavljaju umnažanje bakterija, a da pri tome ne uzrokuju značajnu štetu domaćinu. Danas je rezistencija bakterija na antibiotike vrlo raširena, a razvila se ponajviše zbog neracionalne upotrebe antibiotika. Posebnu zabrinutost predstavlja sve češća pojava multiplorezistentnih izolata koji produciraju β-laktamaze proširenog spektra (ESBL). Enterobacteriaceae su heterogena skupina bakterija i česti su uzročnici infekcija mokraćnog, spolnog i probavnog sustava. Cilj istraživanja bio je pružiti uvid u antimikrobnu rezistenciju izolata bakterija Enterobacteriaceae u Hrvatskoj te utvrditi prevalenciju ESBL producirajućih izolata. Izolati bakterija Enterobacteriacae su izdvojeni iz ljudskog urogenitalnog sustava od strane djelatnika Hrvatskog zavoda za javno zdravstvo i ustupljeni su za provedbu eksperimentalnog dijela diplomskog rada. Osjetljivost izolata na antibiotike ispitana je disk-difuzijskom metodom po Kirby-Baueru i metodom dvostrukog disk-sinergijskog testa. Utvrđena je velika rezistencija Enterobacteriacae na β-laktame (ampicilin 100%, svi cefalosporini više od 90%), fluorokinolone (ciprofloksacin 77%, norfloksacin 74% ) i aminoglikozide (gentamicin 44% i amikacin 10%). Samo 10% izolata Enterobacteriaceae produciralo je ESBL.
Abstract (english)	Antibiotics are pharmacological substances that inhibit the multiplication of bacteria without causing significant harm to the host. Today, bacterial resistance to antibiotics is widespread and has mainly developed due to the irrational use of antibiotics. A particular concern is the increasingly frequent occurrence of multi-drug resistant isolates producing extended-spectrum β-lactamases (ESBL). Enterobacteriaceae are a heterogeneous group of bacteria and are common causes of urinary, sexual, and digestive system infections. The aim of the research was to provide insight into the antimicrobial resistance of Enterobacteriaceae isolates in Croatia and to determine the prevalence of ESBL-producing isolates. Enterobacteriaceae bacterial isolates were obtained from the human urogenital system by the staff of the Croatian Institute of Public Health and were provided to me for the experimental part of my thesis. The sensitivity of the isolates to antibiotics was tested using the Kirby-Bauer disk diffusion method and the double disk synergy test. A high resistance of Enterobacteriaceae to β-lactams (ampicillin 100%, all cephalosporins over 90%), fluoroquinolones (ciprofloxacin 77%, norfloxacin 74%) and aminoglycosides (gentamicin 44% and amikacin 10%) was determined. Only 10% of Enterobacteriaceae isolates produced ESBL.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:489556
Study programme	Title: Experimental Biology Study programme type: university Study level: graduate Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of the Faculty of Science
Created on	2023-10-16 11:06:40