Priprava 1,2-disupstituiranih derivata imidazola i benzimidazola

Kolman, Robert Junior

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master's thesis

Priprava 1,2-disupstituiranih derivata imidazola i benzimidazola

Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:360812

Kolman, Robert Junior

University of Zagreb
Faculty of Science
Department of Chemistry

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APA 6th Edition

Kolman, R. J. (2019). Priprava 1,2-disupstituiranih derivata imidazola i benzimidazola (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:360812

MLA 8th Edition

Kolman, Robert Junior. "Priprava 1,2-disupstituiranih derivata imidazola i benzimidazola." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:360812

Chicago 17th Edition

Kolman, Robert Junior. "Priprava 1,2-disupstituiranih derivata imidazola i benzimidazola." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:360812

Harvard

Kolman, R. J. (2019). 'Priprava 1,2-disupstituiranih derivata imidazola i benzimidazola', Master's thesis, University of Zagreb, Faculty of Science, accessed 19 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:360812

Vancouver

Kolman RJ. Priprava 1,2-disupstituiranih derivata imidazola i benzimidazola [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 December 19] Available at: https://urn.nsk.hr/urn:nbn:hr:217:360812

IEEE

R. J. Kolman, "Priprava 1,2-disupstituiranih derivata imidazola i benzimidazola", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:360812

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:360812

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Title	Priprava 1,2-disupstituiranih derivata imidazola i benzimidazola
Title (english)	Synthesis of 1,2-disubstituted derivatives of imidazole and benzimidazole
Author	Robert Junior Kolman
Mentor	Ines Primožič (mentor)
Committee member	Ines Primožič (predsjednik povjerenstva)
Committee member	Predrag Novak (član povjerenstva)
Committee member	Morana Dulić (član povjerenstva)
Committee member	Ivan Kodrin (član povjerenstva)
Granter	University of Zagreb Faculty of Science (Department of Chemistry) Zagreb
Defense date and country	2019-11-06, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Chemistry
Abstract	U okviru ovog rada opisana je priprava N-supstituiranih imidazolskih i benzimidazolskih derivata, te njihova supstitucija u položaju 2. N-metilimidazol preveden je u više reakcijskih koraka u N-metilimidazol-2-karbaldehid, koji je zatim reduciran u odgovarajući alkohol. Nadalje, iz pripravljenog karbaldehida imidazola sintetiziran je amin u reakciji s benzilaminom. Pripravljen je i N-benzilimidazol, N-metilbenzimidazol i njegov 2-karbaldehid te 2- hidroksimetilni derivat. Dodatno, opisana je reakcija analogna Čičibabinovoj aminaciji kao uzrok nastanka nusprodukata u reakciji karboniliranja N-metilbenzimidazola: 1,1'-dimetil- 2,2'-bibenzimidazola i 2-butil-N-metilimidazola. Identifikacija i kontrola čistoće pripravljenih spojeva provedena je standardnim analitičkim postupcima, koji uključuju IR i NMR (1H i 13C (DEPT-Q)) spektroskopiju.
Abstract (english)	In the scope of this work the synthesis of N-substituted derivatives of imidazole and benzimidazole and their substitution at position 2 was described. N-methylimidazole was transformed by multiple reaction steps into N-methylimidazole-2-carbaldehyde, which was subsequently reduced to the corresponding alcohol. Furthermore, the obtained carbaldehyde was used in synthesis of an amino derivative, in reaction with benzyl-amine. Also, synthesis of N-benzylimidazole, as well as N-methylbenzimidazole, his 2-carboxaldehyde and 2- hydroxymethyl derivative was carried out. Additionally, reaction analogous to Chichibabin amination was described as the cause of byproduct formation in N-methylimidazole carbonylation reaction: 1,1’-dimethyl-2,2’-bibenzimidazole and 2-butyl-Nmethylbenzimidazole. Identification and purity control was conducted with standard analytical methods, including IR, NMR (1H and 13C (DEPT-Q)) spectroscopy.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:360812
Study programme	Title: Graduate university studies in chemistry; specializations in: Research programme Course: Research programme Study programme type: university Study level: graduate Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of the Faculty of Science
Created on	2019-11-27 11:29:40