Multiple sclerosis is an extremely severe chronic neurodegenerative disease that affects the central nervous system. It varies from person to person, so the clinical course of the disease is not easy to predict. It is characterized by multifocal demyelinating white matter lesions. It often causes disability, and symptoms vary among different types of the disease. It occurs at all ages, and most often between the ages of 20 and 50. There are different types of multiple sclerosis: relapsing-remitting, secondary-progressive, primary-progressive and progressive-relapsing form of multiple sclerosis. The approach to patient care is complex and includes physical therapy interventions and lifestyle changes. There are various treatments for the disease, from immunomodulating drugs to complementary approaches. Physical and cognitive rehabilitation are very important. The diagnosis is based on clinical findings that show the spread of the disease over time. The most famous diagnostic criteria are McDonald's criteria. Physiotherapy assessment includes subjective and objective examination. Various measurements and tests are used to assess the patient's overall functional status. After that, an analysis is carried out and a treatment plan is drawn up, followed by physiotherapy intervention. Physiotherapy interventions are based on strategies to maintain movement, learn motor skills and improve the quality of movement.