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master's thesis
Prionske bolesti u životinja i zoonotski potencijal
Zagreb: University of Zagreb, Faculty of Veterinary Medicine, 2022. urn:nbn:hr:178:969197
Glotz, Elizabeta
University of Zagreb
Faculty of Veterinary Medicine

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Glotz, E. (2022). Prionske bolesti u životinja i zoonotski potencijal (Master's thesis). Zagreb: University of Zagreb, Faculty of Veterinary Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:178:969197

Glotz, Elizabeta. "Prionske bolesti u životinja i zoonotski potencijal." Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:178:969197

Glotz, Elizabeta. "Prionske bolesti u životinja i zoonotski potencijal." Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:178:969197

Glotz, E. (2022). 'Prionske bolesti u životinja i zoonotski potencijal', Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, accessed 20 September 2024, https://urn.nsk.hr/urn:nbn:hr:178:969197

Glotz E. Prionske bolesti u životinja i zoonotski potencijal [Master's thesis]. Zagreb: University of Zagreb, Faculty of Veterinary Medicine; 2022 [cited 2024 September 20] Available at: https://urn.nsk.hr/urn:nbn:hr:178:969197

E. Glotz, "Prionske bolesti u životinja i zoonotski potencijal", Master's thesis, University of Zagreb, Faculty of Veterinary Medicine, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:178:969197

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Metadata
TitlePrionske bolesti u životinja i zoonotski potencijal
Title (english)Prion disease in animals and zoonotic potential
AuthorElizabeta Glotz
MentorVilim Starešina (mentor)
Committee memberMatko Perharić (predsjednik povjerenstva)
Committee memberSuzana Hađina (član povjerenstva)
Committee memberVilim Starešina (član povjerenstva)
Committee memberJosipa Habuš (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Veterinary Medicine
Zagreb
Defense date and country2022-11-02, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Veterinary Medicine
Veterinary Public Health and Food Safety
Abstract
Goveđa spongiformna encefalopatija i grebež najpoznatije su prionske bolesti od kojih obolijevaju preživači. Prionske bolesti su neurodegenerativne, progresivne bolesti s dugom inkubacijom, očituju se simptomima od strane živčanog sustava, koji su posljedica vakuolizacije neurona te neizbježnim letalnim završetkom. Uzročnik (prion) je proteinska infektivna čestica, koja sama po sebi ne posjeduje genom te se za umnožavanje koristi genomom domaćina. Podrijetlo priona pripisuje se mutaciji PRPN gena, koji kodira Prpc gen. Njegovom mutacijom nastaje netopljiva izoforma Prpc gena, odnosno Prpsc gen. Prpsc zbog velikog udjela beta ploča u svojoj strukturi ima potencijal vezanja na beta ploče drugih proteina što rezultira stvaranjem agregata, histološki vidljivo kao vakuole u neuronima, te još nepoznatim mehanizmom utječe na transformaciju Prpc gena u Prpsc gen. Nakon izrazito duge inkubacije od nekoliko godina nastupa klinički stadij bolesti praćen teškim neurološkim deficitima, a zbog progresivne prirode bolesti i izostanka specifične terapije, bolest završava letalno. Dijagnostika se zasniva na postmortem uzetim uzorcima moždanog tkiva i histološkim dokazom SAF proteina ili Prpsc gena te pomoću imunohistokemijske metode i Western blot metode. Suzbijanje se zasniva na profilaktičnim mjerama.
Abstract (english)
The two best-known prion diseases among ruminants are Bovine spongiform encephalopathy and scrapie. Neurodegenerative and progressive diseases with a long incubation period. The cause is a protein-based infective particle (prion) that does not possess its own genome, so it uses the host as a means of multiplication. This proteinbased particle is most likely a result of PRPN Genom mutation, responsible for coding the Prpc gene, thus forming the Prpsc gene. The mutation causes changes in the secondary structure of the protein, producing a large percentage of β - sheet. It exhibits high bonding affinity to other proteins, as a result of a high β - sheet percentage, resulting in the formation of insoluble aggregates. The formation of aggregates thought to yet undeciphered mechanism hinders the Prpc to Prpsc gene transformation. After a long incubation period, lasting a few years, clinical symptoms are manifested as a heavy neurological deficiency, as a result of neuron vacuolization. The outcome is exclusively lethal due to the progressive nature of the disease, and lack of specific therapy. The diagnosis is based on immunohistochemical methods, the Western blot method, and positive, post-mortem, histological brain samples. The suppression of diseases is based on prophylactic measures.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:178:969197
Study programmeTitle: Veterinary Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of Faculty of Veterinary Medicine
Created on2022-11-17 13:35:08

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