Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju

Subotičanec, Valentino

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undergraduate thesis

Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju

Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. urn:nbn:hr:149:692890

Subotičanec, Valentino

University of Zagreb
Faculty of Chemical Engineering and Technology

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APA 6th Edition

Subotičanec, V. (2018). Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:692890

MLA 8th Edition

Subotičanec, Valentino. "Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:692890

Chicago 17th Edition

Harvard

Subotičanec, V. (2018). 'Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:692890

Vancouver

Subotičanec V. Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2018 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:692890

IEEE

V. Subotičanec, "Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:149:692890

Cite this item: https://urn.nsk.hr/urn:nbn:hr:149:692890

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Metadata

Title	Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju
Title (english)	Binder distribution in granules obtained by melting in fluidized bed
Author	Valentino Subotičanec
Mentor	Krunoslav Žižek (mentor)
Committee member	Krunoslav Žižek (predsjednik povjerenstva)
Committee member	Gordana Matijašić (član povjerenstva)
Committee member	Vesna Ocelić Bulatović (član povjerenstva)
Granter	University of Zagreb Faculty of Chemical Engineering and Technology Zagreb
Defense date and country	2018-07-13, Croatia
Scientific / art field, discipline and subdiscipline	TECHNICAL SCIENCES Chemical Engineering Mechanical, Thermal and Separation Processes
Abstract	Ovim istraživanjem sagledano je granuliranje u fluidiziranom sloju s in-situ taljenjem veziva kao moguća procesna tehnologija za pripravu mješavine azitromicin dihidrata i laktoze monohidrata pogodne za izradu tableta dobrih primjenskih svojstava. Dodatni ulazni procesni tokovi su zrak i čvrsti polietilen glikol (vezivo) čiji kolektiv kapljica nastaje in-situ taljenjem. Studij fenomena granuliranja u laboratorijskom mjerilu usmjeren je k pronalaženju uvjeta provedbe procesa, geometrije raspršivanja i svojstava ulaznih procesnih tokova koji će sinergističkim djelovanjem upravljati mikro- i mezorazinskim događajima na povoljan i željeni način te time rezultirati kolektivom postojanih okrupnjenih jedinki, granula laktoze monohidrata u čiju je matricu ugrađena djelatna tvar, azitromicin dihidrat. Uspješno granuliranje provedeno je in-situ taljenjem veziva. Dobiveni su kolektivi većih veličina čestica te izvrsne tecivosti. Termogravimetrijskom analizom određen je sadržaj veziva u granulama različitih veličina. Također, sagledana je raspodjela sadržaja veziva među granulama različitih veličinskih razreda.
Abstract (english)	With this study, fluidized bed granulation by in-situ binder melting is scrutinized as a potential process technology for preparation of azithromycin dihydrate and lactose monohydrate mixture that is suitable for manufacturing of tablets with good end-use properties. Additional inlet process streams are air and solid polyethylene glycol (binder), whose droplet population is formed using in-situ melting. Study of the granulation phenomenon in a lab-scale is focused towards detection of process conditions, spraying geometry and formulation properties that will synergically drive micro- and meso-scale events in a favourable and desired way and therewith result in a collective of stable enlarged entities, lactose monohydrate granule matrices in which the active substance, azithromycin dihydrate, is incorporated. Successful granulation is carried out for in-situ binder melting. Collectives of higher particle sizes and excellent flowability have been obtained. Binder content has been detected in granules of different sizes using thermogravimetric analysis. Binder content distribution among granule sizes has been discussed as well.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:149:692890
Study programme	Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry Course: Environmental chemistry and green technologies Study programme type: university Study level: undergraduate Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
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Repository	Repository of Faculty of Chemical Engineering and Technology University of Zagreb
Created on	2021-06-23 12:05:53