ABSTRACT INTRODUCTION: Acute myocardial infarction is the most common acute form of cardiovascular disease that affects 3 million people globally and occurs due to reduced or stopped blood flow to part of the heart muscle. The mortality rate due to myocardial infarction is significantly reduced due to the success of percutaneous coronary intervention in the removal of coronary artery blockage, but hospital mortality still ranges from 4 to 12%. OBJECTIVE: To evaluate the incidence of acute myocardial infarction in Thalassotherapy Opatija in the period from January 1, 2017. until 01.01.2023. years, and compare the same with respect to gender, age and treatment success. METHODS: The study included subjects who were admitted to the coronary unit of Thalassotherapy in Opatija due to acute myocardial infarction during the specified period. The data required for the research were collected retrogradely using medical documentation and the hospital's IT system, and the statistical processing of the data was carried out in the Statistica program. Hypothesis testing was performed with the non-parametric Mann-Whitney U test and the Fisher exact test at the level of statistical significance of p <0.05 (5%). RESULTS: In the period from 01.01.2017. until 01.01.2023. 5,300 subjects were treated in the angio-room of Thalassotherapy in Opatija, of which 0.70% (n=37) were due to acute myocardial infarction. Of the total number of subjects admitted with a diagnosis of acute myocardial infarction, male subjects made up 80.08%, and female subjects only 18.92%. The average age of subjects was 68.08 years, and due to acute myocardial infarction, 78.38% of subjects over 60 years of age and 21.62% of subjects under 60 years of age were admitted to the angio room. Successful elimination of blood vessel occlusion during PCI occurred in 94.6% of subjects, while death in subjects with acute myocardial infarction occurred in 5.4% (n=2) of subjects. CONCLUSION: Percutaneous coronary intervention is an extremely successful method of treating acute myocardial infarction.