Training where sets are performed to a momentarily muscle failure is considered the most important stimulus for strength development, regardless of other training variables such as volume or intensity. It is suggested that the training is performed with a sufficiently high intensity, such as a muscular failure, maximally recruits available motor units making it easier to adapt. However, it is suggested that while performing compound exercises, some muscles represent a weak link and achieve muscular failure before other muscles. This results in the end of exercise before activation of the maximum number of motor units of all muscles involved. It has therefore been suggested that the use of Pre-exhaustion training might provide greater recruitment of motor units to improve the adjustment. The Pre-exhaustion training is an advanced resistance training method in which two or more exercises are performed in the immediate sequence. It is based on the assumption that a muscular failure in the compound exercise occurs when the weakest involved muscles can no longer apply the necessary force to continue the exercise. Therefore, target muscles can be pre-exhausted by isolation exercise before moving to a compound exercise. This paper presents and explains the mentioned method through relevant scientific literature and is critically evaluated.