Recognition of psychiatric comorbidity in individuals with autism is a challenge because people with autism have difficulties in processing and describing their emotional states. It is therefore necessary to interview the family, as well as to perform frequent, continuous observation and monitoring. Also, symptoms of psychopathology can be masked by their typical symptoms of autistic spectrum. Helpful in the diagnosis can be psychometric instruments (check up lists) and although they may be non-specific, because people from the autism spectrum have difficulty in reciprocal communication, children and adults with autism have difficulties to talk about themself, past, present, or future events. This is why there is currently no scales that are designed to evaluate psychiatric comorbidity for people from autistic spectrum disorder which means that it is necessary for their identification much clinical experience of child and adolescent psychiatrist and the psychiatrist later adulthood to work with a person. Prevention, diagnosis and treatment of mental disorders of persons with autism spectrum requires continuous education and following the latest trends by all members of the multidisciplinary team that takes care of the autistic person.