From today's educational system it is expected balanced knowledge in all fields of personal development that will be applicable in practice. Specific economic conditions have influenced rapid changes in labor market that demands the formation of the optimal number of competent experts from the field of nursing with many generic and specific/professional skills that are continuously trained, so before teachers there is a major challenge in the process of directing and transmission of information to the future generations. New generations prefer combination of traditional methods of teaching and contemporary methods that require a different organization of teaching and management of teaching process in an innovative way, because with the changing of technology, the way in which young people perceive reality is changing too, as well as the way in which teachers are transferring courses. All available media and educational technology should be placed in functions such as: learning how to search for information, learning how to learn, learning how to solve problems and learning research methods in controlled environments under the supervision of teachers. In this context, students should be active participants and not passive observers. It is therefore important to emphasize the role of teachers and the role of students, and to emphasize that the contemporary teaching process is teaching based on the active involvement of students in the process of teaching practice. Teaching that is focused on students is actually mutual cooperation of teachers and students with common goal of achieving desired outcomes. The paper will present innovative methods applicable in teaching vocational subjects in secondary medicine schools, methods such as: project based learning, collaborative learning, problem based learning method, research, case studies, the use of Web 2.0 tools, games and simulations.