Type 2 diabetes is a chronic metabolic disease characterized by insulin-resistance and β-cell dysfunction. Its prevalence is constantly increasing and it is estimated that by 2030 the number of patients in the world will exceed 578 million. Type 2 diabetes is associated with numerous complications, of which the greatest importance is given to those cardiovascular. Cardiovascular diseases are the largest cause of morbidity and mortality in patients with type 2 diabetes. Their incidence is 2-3 times higher in patients with diabetes than in the general population and it is believed that any increase in fasting blood glucose by 1 mmol/L increases risk of cardiovascular incident or death by 17 %. The diagnosis made at the age of 45 is associated with a 6-year shorter life expectancy, and if it is diagnosed in adolescence, life expectancy is shortened by as much as 12 years. The U.S. Food and Drug Administration, along with other regulatory agencies, has decided that all new antihyperglycemics must demonstrate cardiovascular safety. GLP-1 agonists and SGLT-2 inhibitors have been shown to be harmless, even superior in reducing the risk of mortality from cardiovascular causes and reduced the risk development of myocardial infarction, stroke, or heart failure. Numerous smaller studies have been conducted confirming their protective effect on the outcome and development of cardiovascular diseases, as well as better control of their risk factors. Taking all this into account, international and Croatian guidelines have placed them at the top of the algorithm for the treatment of type 2 diabetes.