This paper explains the concept of social entrepreneurship and its role in achieving encouraging changes in the lives of people with disabilities through examples of positive practice in Croatia. It tries to explain the very phenomenon of "social entrepreneurship" as well as its development, characteristics and main specificities of social entrepreneurs. Furthermore, the paper provides a historical and legislative overview of the development of social entrepreneurship in Croatia. The paper clarifies the constructs of the title itself, more precisely defines the selected vulnerable group, which in this paper consists of people with disabilities. Furthermore, the complex concept of quality of life is explained through different dimensions and the specific challenges that this group encounters in order to ultimately better understand the benefits of social entrepreneurship as a response to the aforementioned challenges. Particular importance is attached to separate associations and social cooperatives, whose activities, due to their outstanding success in their goals, contributed to the achievement of integration, reducing discrimination and raising the quality of life of people with disabilities and other vulnerable groups. Ultimately, the paper will mention the advantages of social entrepreneurship in the development and transformation of communities and societies. The conclusion contains the insights gained during the writing of the paper and the use of case studies from practice as the chosen methodology.