Diabetes mellitus is a multifactorial disease characterized by a metabolic disorder carbohydrates, fats, lipids, water and proteins. It belongs to the world's leading public health institutions problems with numerous complications. Skin changes that occur in patients and are associated with a disorder of the circulatory system, neurological events or disorders of the immune system are acanthosis nigricans, diabetic thickened skin, limited joint mobility and scleroderma-like syndrome, diabetic scleroderma, eruptive xanthomas, skin infections, bacterial skin infections, fungal infections skin, diabetic ulcers, microangiopathies and macroangiopathies. Skin diseases of unknown etiology, in associations with diabetes mellitus are lipoid necrobiosis, granuloma annulare, diabetic dermopathy, acquired perforating dermatosis, dermatomycosis, diabetic bullae, glucagonoma syndrome. The aim of this paper is to point out the importance of skin changes as a consequence of the existence of the disease itself diabetes mellitus, and at the same time the importance of skin diseases in association with diabetes mellitus. The role of the nurse in the care of DM patients with educational activity, as well as a broad assessment related to the quality of life is emphasized. Biological, psychological, social diversity of patients and their living conditions have to be included and approach to the patient is individual, without a general fit into the scheme of the disease.